2.2.8 2C-I

2C-I #

Common Nomenclature 2,5-Dimethoxy-4-iodophenethylamine
Street & Reference Names 2ci; Smiles
Reference Dosage Threshold 2mg+; Light 5mg+; Common 10mg+; Strong 20mg+ [Erowid]
Typical 5mg-20mg [Drugs-Forum]
Anticipated: Onset / Duration 1 Hour / 8 Hours
Maximum Dose Experienced 9mg *[See also 4.10 Supplementary Notes]
Form Pill
RoA Oral
Source / Jurisdiction Dealer / Overseas


First synthesised by Alexander Shulgin in 1976, 2C-I began to emerge as a popular recreational drug in the late 1990’s. Sometimes confused with 2C-I-NBOMe and dubbed with the name Smiles by the media, it was no surprise when it was scheduled in the United States in 2012. It had already been classified in the UK in 1998.

My sample came in the form of an 18mg pill, reputedly sourced from China and pressed in the UK. I tested it on a swelteringly hot summer’s day; the sort of day on which it is difficult to escape the background heat. This was one of the reasons I went low with the dose: uncomfortable body load could well be multiplied in such conditions.

T+0:00 I weigh the pill and then break it into pieces, accumulating 9mg on the scales. I swig the crumbled debris down with spring water. The operation isn’t particularly clean and I catch the unpleasantness of the taste and constitution of the pill at the back of my throat. [15:20]

T+0:20 Only the mildest of mental stimulation is apparent, but I do feel a little more comfortable with the conditions.

T+0:40 The hazy headspace has only developed a little, but there is now a light sheen to vision.

T+1:00 There is a sweaty touchy feel to this, with the familiar dreamy 2C type of mindset, which is quite smooth, although unexciting. Rationality is fully maintained, although as is often the case with 2C’s, concentration upon specific external factors or subject matter can be heightened from time to time.

I hesitate to use the word comfortable again, but that is the general vibe as I walk around. There are no real visuals to report.

T+1:15 This is quite a physical experience: sentient, clammy hands, with horn available. The headspace is now more solid and the sheen on my vision has strengthened, but not into any definable OEVs or CEVs.

It is quite pleasant at this point. I notice that my pupils are semi-dilated.

T+2:00 I have been on a plateau for some time. This will clearly go no further. It is stable with the mild dreamy mood and the tactile body warmth.

T+3:00 I have now started to slide down the gears. The gentle psychedelic headiness remains, as does the warmth and sensuality, but at increasingly lower levels.

T+5:00 I bathe in the afterglow, with the dying embers of enhanced colouration and the soft landing of the head and body high flowing down towards base.

With certain senses enhanced and anxieties chased away a walk into suburbia becomes a genuine pleasure.

I retire to bed at 11:30pm, eight hours after initial ingestion.

T+16:00 I drifted off fairly quickly and the night’s sleep was a good one. This morning I feel completely normal.

Overall, on this dose this was a fairly mild and pleasant experience. It didn’t have the depth of, for example, 2C-E, or indeed, a great deal of excitement, but for a gentle afternoon sojourn it was positive and enjoyable.

For a fully engaged psychedelic ride I suspect that the consensus, of a dose of perhaps 12-15mg, is probably about right.

[Shulgin Reference: PiHKAL - #33 (Page 539)]