2.7.9 Mexedrone

Mexedrone #

Common Nomenclature Mexedrone
Street & Reference Names N/A
Reference Dosage Light 50mg+; Common 80mg+; Strong 120mg+ [Insufflated, TripSit]
Threshold 50mg+ Light 100mg+; Common 150mg+; Strong 250mg+ [Oral, Psychonautwiki]
Anticipated: Onset / Duration 5 Minutes / 3 Hours
Maximum Dose Experienced 50mg+ 100mg+ 100mg+ 100mg
Form Powder
RoA Insufflated
Source / Jurisdiction Internet / UK
Personal Rating On Shulgin Scale +


Mexedrone’s release in 2015 was accompanied by a sustained period of Internet generated hype. This included the suggestion of close association with mephedrone, with domain names even being registered along these lines (e.g. mcat2.com). Market expectation was therefore extremely high.

However, it was to prove to be disappointing, with only mild effects, and for many, none whatsoever.

The following is a compressed version of my own trip report from that time, as posted on a popular forum:

A joy of a short acting RC is that it can be experienced during a smaller window of opportunity. Courtesy of a sample generously provided by a well known vendor, I was able to perform such a test yesterday afternoon.

My chosen RoA was not my usual preference, which is oral. I insufflated simply because I had eaten a heavy lunch, which I felt might dilute the effect of the drug.

T+0.00 I crush the crystals and insufflate 50mg to establish the broad headspace and the feel of the experience.

T+0.05 I sense my mood being gently elevated. There is no stimulation at this point, just a barely perceptible shift towards positivity.

T+0.30. As the same sort of mild background feeling has persisted for the best part of half an hour, I insufflate a further 100mg.

T+1.00 The warm positive feel has returned but it is a little stronger. It is quite nice, which is perhaps the best description I can find. There is a minor mood enhancement and a warm pleasant feeling compared to base.

I insufflated a couple more 100mg lines during the course of the afternoon, bringing the grand total to 350mg. There was no major urge to redose, but I chose to push a little further out of curiosity. The effects tapered off during the evening.

At these levels this won’t blow your socks off. It isn’t stimulating and doesn’t lift you to the clouds. I do not say this negatively, just factually. The biggest problem this chemical faces is going to be expectation, due to its marketing alignment with 4-MMC. Further, it just isn’t very strong.

I can see why some people suggest similarity to MDAI, but I found it to subtly different, with a little more clarity of mind, and significantly less empathy.

I liked the short duration: for my current lifestyle, writing off a full day, and potentially a night’s sleep, is difficult. For recreation, this can be slipped in for just a few hours, and is totally functional in social situations.

Contrary to my expectation, the night’s sleep was not the best, and this morning I could still feel that I had recently consumed a chemical. This wasn’t terrible, but it was noticeable. Perhaps there was some (latent) stimulation in this after all.

Mexedrone was one of those releases which attracted undue positivity; partly because it was legally and easily available, and partly due to the hype. It wasn’t even close to being a mephedrone replacement, and its mild effects were such that I would seriously question its value in terms of a risk/benefit (much of the risk being that it was a new untested chemical). It certainly isn’t one which I would ever use again.