2.9.11 PRL-8-53

PRL-8-53 #

Common Nomenclature PRL-8-53
Street & Reference Names N/A
Reference Dosage N/A
Maximum Dose Experienced 5mg
Form Powder
RoA Oral
Source / Jurisdiction Internet / UK


PRL-8-53 is purported to improve short term memory, a claim which has been supported via limited trial data:

A single study in humans was reported in 1978. The double-blind trial of PRL-8-53 in 47 healthy volunteers measured its effects on a variety of cognitive measures. 5 mg of the drug was administered orally 2–2.5 hours before the study tasks. Overall improvements in recollection differed based on how many words were recalled under placebo, with the poor performers (six words or fewer) experiencing a 87.5-105% increase in recollection and the high performers (eight or more words) a 7.9-14% increase which failed to reach statistical significance; when controlling for subjects over the age of 30 only, a 108-152% increase was noted. No side effects were reported during the trial.” ~ Wikipedia

Short of engaging a formal testing regime it is impossible to substantiate this. There are, however, many online reports by nootropic enthusiasts to peruse.

I can confirm that I felt no ill effects from the experiment. In terms of positive recreational value, this was minor, and could easily have been a placebo effect. Additional commentary is therefore not justified.